Publication

A clinically relevant morpho-molecular classification of lung neuroendocrine tumours

Alexandra Sexton-Oates, Émilie Mathian, Noah Candeli, Yuliya Lim, Catherine Voegele, Alex Di Genova, Laurane Mangé, Zhaozhi Li, Tijmen van Weert, Lisa M. Hillen

July 2025 medRxiv
Abstract

Study summary

This preprint integrates genomics, transcriptomics, methylation, spatial profiling, morphology, and clinical data to refine the classification of lung neuroendocrine tumours. The proposed morpho-molecular groups expose clinically relevant tumour states and potential therapeutic opportunities, including markers connected to prognosis and treatment selection.